Chadwick C Prodromos
Rush University Medical Center | Rush · Department of Orthopaedic Surgery
Tobias Rumschlag
The Foundation For Orthopaedics and Regenerative Medicine · Research
Doctor of Medicine
INTRODUCTION
Hydroxychloroquine (HCQ) has shown efficacy against COVID-19 in some but not all studies. We hypothesized that systematic review would show HCQ to be: effective against COVID-19, more effective used earlier, not associated with worsening, and safe.
METHODS We searched PubMed, Cochrane, EmBase, Google Scholar, and Google for all reports on hydroxychloroquine as a treatment for COVID-19 patients. This included pre-prints and preliminary reports on larger COVID-19 studies. We examined the studies for efficacy, time of administration and safety.
RESULTS HCQ was found consistently effective against COVID-19 when used early, in the outpatient setting. It was found overall effective. No credible study found worse outcomes with HCQ use. No mortality or other serious safety issue was found
CONCLUSIONS HCQ is consistently effective against COVID-19 when used early in the outpatient setting, it is overall effective against COVID-19, it has not produced worsening, it is safe.
Rush University HCQ by Juana Atkins on Scribd
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